Boston Startup Hub

Welcome to the hub for the most groundbreaking and ambitious startups in Boston! Our directory has just landed, want to join us on this exciting journey?

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Featured Startups

Dive into our directory to uncover more innovations that are shaping the city's future.

Emulate

Healthcare

Emulate

Emulate Inc. is a privately held company that creates advanced in vitro models for understanding how diseases, medicines, chemicals, and foods affect human health. Our lab-ready Human Emulation System® includes three components: Zoë® Culture Module, Organ-Chips, and analytical software applications. The platform provides a window into the inner workings of human biology and disease—offering researchers a new technology designed to predict human response with greater precision and detail than conventional cell culture or animal-based experimental testing. Research conducted using our Organ-Chips has been published in high-impact scientific journals, including Science. In addition, Organ-Chips have been acquired by the Museum of Modern Art (MoMA) in New York for their permanent collection and have also been awarded Product Design of the Year 2015 by London’s Design Museum.

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BlockJoy

Blockchain

BlockJoy

BlockJoy allows you to deploy and run your own blockchain nodes on any infrastructure you choose. It started as a project to manager staking with friends and family. We built advanced tooling to optimize validator management for teams of two. But, due to the sheer difficulty of installing and running nodes, our little VaaS company grew crazy fast. We quickly realized that VaaS can’t work for a network because it centralizes control. We turned our platform into a SaaS tool so that anyone could launch and run their own node with full control over where and on what infrastructure it runs. Now, network operators can run their own nodes; BlockJoy just takes the headaches away.

Asimov

Biotech

Asimov

Headquartered in Boston, Asimov's mission is to advance humanity's ability to design living systems, enabling biotechnologies with outsized societal benefit. The company is developing a synthetic biology platform – from cells to software – to design and manufacture next-generation therapeutics, including biologics, cell/gene therapies, and RNA. Founded by bioengineers from MIT and Boston University, the company has raised over $200 million from top institutional investors including Andreessen Horowitz, CPP Investments, Horizons Ventures, and Fidelity Management & Research Company. Asimov builds tools to program living cells. By integrating mammalian synthetic biology, computer-aided design, and machine learning, our multi-disciplinary team is advancing the design and manufacture of biologics and gene therapies.

Sense Energy

Electronics

Sense Energy

Sense's mission is to make all homes intelligent by keeping people informed about what's happening in their homes and helping to make them safer, more efficient, and more reliable. Sense was born from the simple idea that people should know what's happening in their homes. We track calories, footsteps, mpg's yet we know so little about the place where we spend so much time. Energy efficiency and home automation begin with information. We built the Sense home energy monitor to provide people with information about their homes in the simplest, most helpful way possible.

HqO

Real Estate

HqO

HqO is transforming how people connect with each other and the places they work. The HqO Workplace Experience Platform makes it easy for companies and commercial property teams to create modern workplaces through world-class amenities and services that allow people to thrive and do their best work. Active in over 200 million square feet in 25 countries, 57% of the Fortune 100 rely on HqO to enhance their workplace experiences, improve employee satisfaction, and drive operational excellence.

Rezonate

Software

Rezonate

Rezonate.io is a cutting-edge Identity Centric Security Platform designed to fortify both human and machine identities against cyber threats throughout their entire access journey to business assets. With a bold proclamation that "A/B Testing is Dead," Rezonate.io champions a shift from traditional methods to AI-driven solutions. Their platform offers comprehensive features such as real-time monitoring of privileges and activities, risk reduction, and active threat mitigation. Recognized as a "Cool Vendor" in the 2023 Gartner® Cool Vendors™ in Identity-First Security report, Rezonate.io is committed to delivering an all-encompassing identity-first security platform that bolsters security posture, fortifies defense mechanisms, and facilitates effective threat remediation. Rezonate.io's platform is uniquely designed to discover, profile, and protect identities, ensuring secure access to cloud infrastructure and critical SaaS applications. It provides continuous exposure reduction by uncovering and rectifying weak authentication, misconfigured trust relations, and other vulnerabilities. Moreover, the platform's adaptive access engine optimizes security controls, ensuring that identities are managed efficiently.

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July 22nd, 2025

Boston Tech Talks: Arnar Larusson from Tyme Wear

In this edition of Boston Tech Talks, Arnar Larusson, co-founder of Tyme Wear, shares how his background in biomechanics and engineering led to building a wearable tech startup—and why Boston’s unique mix of resources, talent, and community made it the ideal place to launch.